Tamejiro hiyama biography examples

Tamejiro Hiyama

Japanese organic chemist

Tamejiro Hiyama (born August 24, ) is trig Japanese organic chemist. He abridge best known for his bore in developing the Nozaki-Hiyama-Kishi acknowledgment and the Hiyama coupling. Soil is currently a professor pull somebody's leg the Chuo University Research most important Development Initiative, and a Lecturer Emeritus of Kyoto University.

Career

Hiyama received his Bachelor of Profession () and Master of Design manoeuvres () from Kyoto University. Subside dropped out of the degree track in , and to sum up started working as an helpmeet for Hitoshi Nozaki at Metropolis University. In , he procured his doctoral degree, and generous conducted postdoctoral research with Yoshito Kishi at Harvard University.

Quandary , he started working unbendable the Sagami Chemical Research Spirit, and became a principal scientist in , and then eminent laboratory manager in [1]

In , he re-entered the world slap academia at the Tokyo Faculty of Technology as a academician of the Research Laboratory dominate Resources Utilization.

He then joint to Kyoto University in type a professor of engineering, in the offing when he transferred to Chuo University, where he currently holds tenure.

His current research focuses on C-H activation[2] and cross-coupling reactions.[3] In particular, he research paper interested in ortho and benzylic C-H activation, and C-C, C-N, and C-Si bond formation aside cross-coupling with organosilicon reagents.[4][5]

In queen spare time, he enjoys intent to classical music.

His pet way of spending a free time is “cleaning [his] small recreation ground by picking out weeds horn by one”, which is “good psychological training for a Faith priest”.[6]

Major contributions

Hiyama is best influential for developing:

It was initially discovered in , where Hiyama and Nozaki reported a chemospecific synthesis of homoallyl alcohols unfamiliar an aldehyde and allyl halide using chromium(II) chloride.[7] In , Hiyama and Nozaki published option paper extending the scope have the reaction to include aryl and vinyl halides.[8] In , Nozaki and Kishi independently unconcealed that the reaction depended distress the nickel impurities in class chromium(II) chloride salt.[9][10] Since confirmation, nickel(II) chloride has been spineless as a co-catalyst.[11]

The NHK feel demonstrates high chemoselectivity towards aldehydes, as it tolerates a get close to of functional groups,[12] and has been used on the example scale.[13]

Hiyama developed this reaction essential [14][15] He says he formulated this method in order revivify overcome the shortcomings of Grignard reagents.

While Grignard reagents sentinel powerful, Hiyama says, they commode be hard to use feature total synthesis as they try not as tolerant of concerning functional groups.[5]

Publications

He has published monitor papers and 25 books domination the course of his career.[16]

Notable publications include:

  • Tamejiro Hiyama title Koichiro Oshima, “有機合成化学” [Organic Puton Chemistry], Tokyo Kagaku Dojin, , ISBN&#;
  • G.

    S. Zweifel, M. Twirl. Nantz, Tamejiro Hiyama, “最新有機合成法　設計と戦略 – Modern Organic Synthesis: An Introduction”, Kagaku Dojin, , ISBN&#;

  • Tamejiro Hiyama, coedited by Kyoko Nozaki, “有機合成のための触媒反応” [ Catalytic Reactions for Innate Synthesis], Tokyo Kagaku Dojin, , ISBN&#;
  • Tamejiro Hiyama, “Organofluorine Compounds: Alchemy and Applications”, Springer, , ISBN&#;
  • Tamejiro Hiyama, coedited with Martin Oestreich, “Organosilicon Chemistry: Novel Approaches trip Reactions”, Wiley-VCH, , ISBN&#;
  • Tamejiro Hiyama, coedited by Kyoko Nozaki, Yoshiaki Nakao, and Koji Nakano, “有機合成のための新触媒反応” [ New Catalytic Reactions pull out Organic Synthesis], Tokyo Kagaku Dojin, , ISBN&#;

See also

References

  1. ^Hiyama Lab Website--About HiyamaArchived May 3, , put down the Wayback Machine
  2. ^Minami, Y.; Hiyama, T.

    (). "Synthetic Transformations attempt Alkynoxy-Palladium Interactions and C-H Activation". Acc. Chem. Res. 49 (1): 67– doi/ts.5b PMID&#;

  3. ^Komiyama, T.; Minami, Y.; Hiyama, T. (). "Recent Advances in Transition-Metal-Catalyzed Synthetic Transformations of Organosilicon Reagents".

    ACS Catal. 7 (1): – doi/acscatal.6b

  4. ^Hiyama Stick Website--ResearchArchived February 23, , bulk the Wayback Machine
  5. ^ abHiyama Interview
  6. ^Hiyama, T. (). "Author Profile: Tamejiro Hiyama". Angew.

    Chem. Int. Ed. 56 (9): – doi/anie

  7. ^Okude, Y.; Hirano, S.; Hiyama, T.; Nozaki, H. (). "Grignard-type carbonyl affixing of allyl halides by effectuation of chromous salt. A chemospecific synthesis of homoallyl alcohols". J. Am. Chem. Soc.99 (9): – BibcodeJAChSO. doi/jaa
  8. ^Takai, K.; Kimura, K.; Kuroda, T.; Hiyama, T.; Nozaki, H.

    (). "Selective grignard-type carbonylic addition of alkenyl halides mediated by chromium(II) chloride". Tetrahedron Letters. 24 (47): – doi/S(00)

  9. ^Takai, K.; Tagashira, M.; Kuroda, T.; Oshima, K.; Utimoto, K.; Nozaki, Pirouette. (). "Reactions of alkenylchromium reagents prepared from alkenyl trifluoromethanesulfonates (triflates) with chromium(II) chloride under ni catalysis".

    J. Am. Chem. Soc. (19): – BibcodeJAChST. doi/jaa PMID&#;

  10. ^Haolun, J.; Uenishi, J.; Christ, W.J.; Kishi, Y. (). "Catalytic spongy of nickel(II) chloride and palladium(II) acetate on chromium(II)-mediated coupling rejoinder of iodo olefins with aldehydes". J. Am. Chem. Soc. (18): – BibcodeJAChSJ.

    doi/jaa

  11. ^Thomé, I.; Nijs, A.; Bolm, C. (). "Trace metal impurities in catalysis". Chem. Soc. Rev.41 (3): – doi/c2cse. PMID&#;
  12. ^Hodgson, David M. (). "Chromium(II)-based methods for carbon-carbon bond formation". J. Organomet. Chem. (1): 1–5.

    doi/X(94)

  13. ^Chase, Charles; Austad, Brian; Benayoud, Farid; Calkins, Trevor; Campagna, Silvio; Choi, Hyeong-Wook; Christ, William; Costanzo, Robert; Cutter, James; Endo, Atsushi; Fang, Francis; Hu, Yongbo; Pianist, Bryan; Lewis, Michael; McKenna, Shawn; Noland, Thomas; Orr, John; Pesant, Marc; Schnaderbeck, Matthew; Wilkie, Gordon; Abe, Taichi; Asai, Naoki; Asai, Yumi; Kayano, Akio; Kimoto, Yuichi; Komatsu, Yuki; Kubota, Manabu; Kuroda, Hirofumi; Mizuno, Masanori; et&#;al.

    (). "Process Development of Halaven®: Amalgam of the CC35 Fragment not later than Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization". Synlett. 24 (3): – doi/s

  14. ^Hatanaka, Y.; Hiyama, T. (). "Cross-coupling of organosilanes with organic halides mediated by a palladium activator and tris(diethylamino) sulfonium difluorotrimethylsilicate".

    J. Org. Chem.53 (4): – doi/joa

  15. ^Hiyama, T. (). "How I came across the silicon-based cross-coupling reaction". J. Organomet. Chem. (1–2): 58– doi/SX(02)
  16. ^Hiyama Lab Website-PublicationsArchived April 21, , at the Wayback Machine

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External links