| Year | Title | Role | Notes |
|---|
| 1986–1989 | Miami Vice | Orlando Calderone, Angelo Alvarez | 3 episodes |
| 1991 | Mambo Mouth | Various characters | Television integument |
| 1993 | Spic-O-Rama | Television special |
| 1995 | House of Buggin' | Creator, writer, producer; 10 episodes |
| 1997 | All That | Mocking Unfamiliar | 1 episode |
| 1998 | Freak | Himself | Television film |
| 2000 | Arabian Nights | Genie bear out the Ring/Genie of the Alight | Miniseries; 2 episodes |
| 2000–2004 | The Brothers Garcia | Narrator | 45 episodes |
| 2002 | Sesame Street | Himself/Captain Vegetable | Episode: "Snuffy's Grandma Visits" |
| 2002 | Sexaholix...
Spiffy tidy up Love Story | Himself | Television film |
| 2004 | Dora the Explorer | Flying Monkeys, Letter Bird, Pirate Pig | Voice, 3 episodes |
| 2004 | Lugar Heights | Spanish Sweep | Voice, 1 episode |
| 2005–2006 | ER | Dr.
Victor Clemente | 12 episodes |
| 2006 | My Name Is Earl | Uncle Diego | Episode: "South of the Border" |
| 2007 | The Kill Point | Mr. Wolf | 8 episodes |
| 2011 | Ice Age: Unornamented Mammoth Christmas | Sid | Voice, TV special[2] |
| 2012 | Kings of Van Nuys | Del Boy | Unaired pilot |
| 2013 | American Dad! | Luis Ramirez | Voice, episode: "The Full Intellectual Redaction of Avery Bullock get ahead of the Coward Stan Smith" |
| 2014 | Sanjay and Craig | Carlos Bandana | Voice, episode: "Tuffcon"[2] |
| 2014 | John Leguizamo's Ghetto Klown | Himself | Television film |
| 2015 | The Adventures of Puss in Boots | Jack Sprat | Voice, 3 episodes[2] |
| 2016 | Ice Age: The Great Egg-Scapade | Sid | Voice, correspondents special[2] |
| 2016–2017 | Bloodline | Ozzy Delvecchio[19] | 17 episodes |
| 2016–2017 | Live with Kelly | Himself | Guest crush |
| 2018 | Waco | Jacob Vazquez[20] | Miniseries; 3 episodes |
| 2018 | Animals | Fluffy | Voice, episode: "Dogs"[2] |
| 2018 | BoJack Horseman | Mr.
Buenaventura | Voice, episode: "Planned Obsolescence" |
| 2018 | Latin Representation for Morons | Himself | Netflix stand-up illusion |
| 2019 | When They See Us | Raymond Santana Sr. | Miniseries |
| 2020 | Elena of Avalor | Tziloco | Voice, episode: "Giant Steps" |
| 2020 | The Mandalorian | Gor Koresh | Voice, episode: "Chapter 9: Rectitude Marshal"[21] |
| 2021 | Inexplicable: Latinoamerica | Himself | Host |
| 2021–2022 | Fairfax | Glenn the Pigeon | Voice, eternal role[22] |
| 2023 | The Power | Dr.
Rob Lopez | Main role[23] |
| 2023 | The Daily Show | Himself | Guest host (week handle March 27)[24] |
| 2023–present | Leguizamo Does America | Host |
| TBA | Firebug | Esposito | Upcoming miniseries[25] |